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There is no doubt that numbers have significance in the Old and New Testaments. We see this in the typological prefiguration of New Testament realities. For example, Moses was with the Lord forty days and forty nights on Mount Sinai, receiving the Ten Commandments (Exod. 34:28). Similarly, Jesus Christ, the new Moses (see Deut. 18:15-19), spends forty days fasting in the desert before inaugurating his public ministry (Matt. 4:1-11), in which he fulfills the law (Matt. 5:17-18).
But pay no need to books like Michael Drosnin’s The Bible Code. Jesus established his Catholic Church on the apostles to teach all that he commanded (Matt. 28:18-20, Acts 2:42), sending them the Holy Spirit to lead them into all truth (John 16:13). So God gives any truth we need to know in the Bible regarding our salvation through his Church. That there is more divine revelation embedded in the Bible to be accessed only in the latter days by means of a mathematical code applied to Scripture is simply contrary to the teachings of Christ (see CCC 66-67).